Alpha Particles Induced Modification on SSNTDs Stored for Long Time
A.
Maged
Egyptian Atomic Energy Authority
author
text
article
2017
eng
E FFECTS of ageing on the optical properties of CR-39 SSNTDs were investigated for two stored types. The optical band gap of the stored pristine was roughly the same as the new pristine samples before chemical etching. Energy gaps were found to decrease with the chemical etching. The onset of the transmittance spectra of the CR-39 SSNTDs were measured at 240 nm and 300 nm for 26 y and 10 y respectively. The etch pit diameters of α−particles were deceased with the storage period while the rate of the decrease depended markedly on the storage conditions. The fading effects of tracks due to radon exposure were a little bit changed. The storage at the temperature of 4 °C for 26 y did not bring any significant changes to the detection efficiency. These characterizations of the response of CR-39 SSNTDs to alpha particle were essential for the storage under certain conditions.
Egyptian Journal of Radiation Sciences and Applications
The National Centre for Information and Documentation (NIDOC), The Academy of Scientific Research and Technology (ASRT)
1110-0303
30
v.
2
no.
2017
109
115
https://ejrsa.journals.ekb.eg/article_4710_988a5b1049d5b9d255144e5aba6b7beb.pdf
dx.doi.org/10.21608/ejrsa.2017.584.1000
In Silico Study and Preclinical Evaluation of Radioiodinated Procaterol as a Potential Scintigraphic Agent for Lung Imaging
Mahmoud
Sanad
Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
author
Gehan
Saleh
Health Radiation Research department (Radiodiagnosis Unit), National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
author
Hanan
Tallat
Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo-Egypt.
author
text
article
2017
eng
PROCATEROL has been labeled using [125/131I] with chloramine-T (Ch-T) as oxidizing agent which can be used for lung imaging instead of the commercially available complex (Macro-aggregated albumin complex,99mTc-MAA) which is called blood-derived product. In addition, a comparison between a new radiotracer and other radiotracers such as 99mTc-DHPM,99mTc(CO)5I , 125/123I-IPMPD, 125I-fenoterol ,125I-reproterol, 125I-levalbuterol, 99mTc-levosalbutamol and 99mTc-tricarbonyl levosalbutamol is conducted. Factors such as the amount of oxidizing agent(100 μg), amount of substrate (100 μg), pH of reaction mixture (4), ambient temperature and reaction time (15min), have been systematically studied to optimize the iodination. Additionally, the in-vitro stability of radioiodinated procaterol was studied in two different media , namely, saline and serum up to 72 hours that indicates its stability upto 12hr. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoreses and high performance liquid chromatography (HPLC). Biodistribution studies indicated the suitability of radioiodinated procaterol as a novel tracer for lungs imaging. Radioiodinated procaterol could be considered a new radiotracer for lung imaging.
Egyptian Journal of Radiation Sciences and Applications
The National Centre for Information and Documentation (NIDOC), The Academy of Scientific Research and Technology (ASRT)
1110-0303
30
v.
2
no.
2017
117
130
https://ejrsa.journals.ekb.eg/article_4711_a654238579492d98b230c0850632b68c.pdf
dx.doi.org/10.21608/ejrsa.2017.1500.1016
Radioiodination, Molecular Modelling and Biological Evaluation of Aniracetam as a Tracer for Brain Imaging
Mahmoud
Sanad
Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt.
author
Ayman
Farag
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
author
Dina
Husseiny
Health Radiation Research department (Radiodiagnosis Unit), National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt
author
text
article
2017
eng
THE PRESENT study focused on synthesis of radioiodinated aniracetam for a potential brain imaging. Aniracetam (AN) has been labeled using [125I] with chloramine-T (Ch-T) as an oxidizing agent. The key effective factors such as amount of oxidizing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to get high radiochemical yield of the radioiodinated aniracetam. The obtained results show a high radiochemical yield of iodoaniracetam that reached 98%. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoreses and high performance liquid chromatography (HPLC). Docking and modeling with AMPA receptors, gamma camera and drug inhibition were studied. In vivo biodistribution of radioiodinated aniracetam was evaluated in Swiss albino mice. The biodistribution results show a brain uptake that reached 9.50 ± 0.17 %ID/g at 15 min post injection (p.i.). Based on these results, it can be stated that radioiodinated aniracetam could be efficiently used as a potential radiotracer drug for brain imaging.
Egyptian Journal of Radiation Sciences and Applications
The National Centre for Information and Documentation (NIDOC), The Academy of Scientific Research and Technology (ASRT)
1110-0303
30
v.
2
no.
2017
131
143
https://ejrsa.journals.ekb.eg/article_4712_deac9c778643c47bc3034ebd09712895.pdf
dx.doi.org/10.21608/ejrsa.2017.1523.1017
Properties of Acrylonitrile Butadiene Rubber Modified with Acrylate Monomers and Oligomers Using Gamma Irradiation
Khaled
EL-Nemr
Radiation chemistry department, NCRRT, EAEA
author
Hamdi
Radi
Radiation chemistry department, EAEA
author
Issa
Mousa
Radiation Chemistry Department, NCRRT, EAEA
author
text
article
2017
eng
ACRYLONITRILE butadiene rubber (NBR) is commonly used as oil and fuel resistant in industrial applications. This study is carried out to investigate the effect of adding some acrylate monomers and oligomers that was used by constant concentration, namely (0.02 mol /100 g of rubber) to improve the physical and mechanical properties of (NBR) reinforced by 30 phr carbon black and mixed in a rubber rol mill, exposed to gamma radiation (doses from 25 to 150 kGy). The results indicated that the acrylate monomers increase the tensile strength (TS) at lower doses up to 50 kGy, while the oligomers increase the TS at higher doses more than 50 kGy. On the other hand, the physical properties such as soluble fraction, swelling ratio and crosslinking density showed dependence on the specific unsaturation (SU) of monomer and oligomer. The thermal stability of the composites tested by thermogravimetric analysis (TGA) recorded comparable values except NBR modified by urethane diacryalte (UDA) have the lowest value.
Egyptian Journal of Radiation Sciences and Applications
The National Centre for Information and Documentation (NIDOC), The Academy of Scientific Research and Technology (ASRT)
1110-0303
30
v.
2
no.
2017
145
152
https://ejrsa.journals.ekb.eg/article_5856_226a96f01a425b999fef5f1870ede78f.pdf
dx.doi.org/10.21608/ejrsa.2018.1749.1019
The Effect of Gamma Radiation on the Shear Bond Strength of Flowable Self-Adhesive Resin Composite
Hazem
Kazem
Health research department, national center for radiation research and technology
author
Eman
Abouauf
Conservative dentistry dept. Cairo university
author
text
article
2017
eng
THIS study is designed to investigate the influence of exposure to therapeutic gamma radiation on a self adhesive resin (Vertise-Flow). Twenty freshly extracted human molars were selected and used in the study. All the sound molars were examined and confirmed free of any cracks or defects. Standardized twenty discs were prepared from the selected molars of 2mm thickness, then a hole of 3mm diameter was prepared in each disc. The twenty holes prepared were restored with Vertise-Flow according to the manufacturer’s instructions. Ten discs were randomly selected and subjected to an exposure dose of gamma radiation simulating the treatment dose delivered to the cancer patients, while the remaining discs were kept as control. Each sample was tested by a compressive loading via computer controlled materials testing machine, with a load of 5 KN. The maximum failure loading was reported in N, while the shear bond strength (SBS) was calculated in MPa. It was found that the SBS of self-adhesive resins were reduced upon exposure to the therapeutic dose of gamma radiation. Yet, the difference was not statistically significant. Using simplified resin restorations as the self-adhesive composite restorations could be an efficient and easy restorative for patients receiving gamma radiotherapy.
Egyptian Journal of Radiation Sciences and Applications
The National Centre for Information and Documentation (NIDOC), The Academy of Scientific Research and Technology (ASRT)
1110-0303
30
v.
2
no.
2017
153
159
https://ejrsa.journals.ekb.eg/article_5857_d0112a16ccefeb050afcbb965213e701.pdf
dx.doi.org/10.21608/ejrsa.2018.1784.1020
Beneficial Effects of Piperine in global cerebral ischemia/reperfusion model in irradiated rats
Samar
Azab
Faculty of Pharmacy - Ain Shams University
author
Walaa
Elsabbagh
Drug Radiation Research Department, NCRRT
author
Mohammed
Abd El-Daim
Faculty of Veterinary Medicine, Suez Canal University
author
Engy
Rashed
National Center for Radiation Research and Technology
author
text
article
2017
eng
Stroke is the third cause of death and a leading cause of chronic disability all around the world. Inflammation and oxidative stress are common pathogenic pathways of brain injury induced by ischemia/reperfusion (I/R). This work aims to investigate the possible role of Piperine as antioxidant and anti-inflammatory in attenuating the cerebral ischemia/reperfusion (I/R)-induced brain injury in whole body γ-irradiated rats. Global cerebral ischemia was induced in both irradiated and non-irradiated male Wistar rats, and was followed by reperfusion. The beneficial effect of pretreatment with piperine (10 mg/kg, once daily p.o. for 15 days) was examined on cerebral ischemia-induced brain injury in 24 h pre-irradiated (6 Gy) male Wistar rats. I/R increased brain content of malondialdehyde (MDA) and decreased its glutathione (GSH) content and total antioxidant capacity (TAC). It also raised serum lactate dehydrogenase (LDH) activity and brain cytosolic calcium (Ca2+) level. Pre-treatment with piperine significantly attenuated brain injury in I/R irradiated rats by decreasing cytosolic brain calcium level and serum lactate dehydrogenase (LDH) activity. In addition, a significant decrease in nuclear factor kappa-B (NF-kB) was recorded in piperine treated group. These findings indicate that administration of piperine ameliorated most of the tested biochemical changes induced by I/R in irradiated rat brain and serum.
Egyptian Journal of Radiation Sciences and Applications
The National Centre for Information and Documentation (NIDOC), The Academy of Scientific Research and Technology (ASRT)
1110-0303
30
v.
2
no.
2017
161
170
https://ejrsa.journals.ekb.eg/article_4714_200a89de65f15e501dcc62c4082668ac.pdf
dx.doi.org/10.21608/ejrsa.2017.2052.1026
Measurement of Vitamin D and Antioxidants Levels in Discoid Lupus Erythematosus Patients
Dina
Elessawi
Health radiation research department, National Centers for Radiation Research and Technology , Atomic Energy Authority.
author
Nashwa
Radwan
Dermatology unit, Health radiation research department, National Centers for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA).
author
Iman
Bassyouni
Rheumatology and Rehabilitation department, Faculty of medicine, Cairo University
author
text
article
2017
eng
DISCOID Lupus Erythematosus (DLE) is a chronic dermatological disease that can lead to scarring, hair loss, and hyperpigmentation changes in skin if it is not treated early and promptly. Diagnosis of discoid lupus is generally made based on clinical features. Sometimes, tests are required, including blood and urine samples. Similar to other many autoimmune conditions, DLE is generally a lifelong condition. However, there are treatments available that are usually effective and can help keep symptoms under control. IL-17 isoforms (IL-17A and IL-17F) are implicated in DLE.Active Vitamin D3 (1, 25(OH) 2D3) is a fat-soluble vitamin that its principle action is to increase the absorption of calcium and phosphate ions from the intestine and directly affect the calcification process. Beside its crucial role in calcium metabolism and bone remodeling, active vitamin D3 is considered an immunomodulator. Increased reactive oxygen species (ROS), lipid peroxides, and low antioxidant status occur in autoimmune disorder.This study aims to assess the level of vitamin D3 [25(OH) D3] in Discoid Lupus Erythematosus (DLE) patients compared to normal controls, its correlation with disease activity parameters, laboratory parameters and antioxidants levels.Twenty patients with (DLE) and 20 healthy controls matched for age and gender were included into this prospective study. Serum vitamin D3 [25(OH) D3] is measured as it is the precursor of active vitaminD3 [1, 25(OH) 2D3] which has a very short half-life. Oxidative stress was assessed by measuring serum malondialdehyde (MDA) and enzymatic antioxidant status by estimating superoxide dismutase (SOD) and glutathione peroxidase (GPX).The results of the present work are highly suggestive of the importance of vitamin D3 supplementation in (DLE) and the importance of topical antioxidants to control flare in DLE patients.The serum levels of vitamin D3, SOD, and GPX were significantly lower in DLE patients when compared to their levels in the control group (p< 0.000) .On the other hand, MDA was significantly higher in the DLE patients than that in the healthy control subjects (p<0.001). A highly statistical negative correlation between vitamin D3 with MDA level (P <0.004and r = -0.615) was observed. On the other hand, SOD and GPX positively correlated with vitamin D3 level (P < 0.001 and P<0.000 respectively and r = 0.680 and 0.734 respectively).It could be suggested that low vitamin D3 and disturbed antioxidant levels are prevalent in the Egyptian DLE patients. There is a clear association between vitamin D3 and antioxidants with different signs of disease activity. A routine vitamin D3 and antioxidant supplementations are recommended to DLE patients for better prognosis.
Egyptian Journal of Radiation Sciences and Applications
The National Centre for Information and Documentation (NIDOC), The Academy of Scientific Research and Technology (ASRT)
1110-0303
30
v.
2
no.
2017
171
182
https://ejrsa.journals.ekb.eg/article_5201_21658d4482a189fbbb2be1da44bb3298.pdf
dx.doi.org/10.21608/ejrsa.2017.2023.1027