Reform of Hematopoietic, Apoptotic and Oxidative Disturbance Induced by Accumulated γ-irradiation in Rat’s Bone Marrow via Curative Efficacy of Bradykinin Potentiating Factor Isolated from Bee Venom

Document Type : Original Article

Authors

1 Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

2 Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

Abstract

BEE venom contains a strong bradykinin-potentiating factor (BPF). In previous studies, BPF isolated from scorpion venom has been shown to be protective against hepato- and nephrotoxicity by reducing oxidative stress. Therefore, the authors aimed at evaluating the novel ability of BPF isolated from bee venom in treating oxidative and apoptotic defects induced by accumulated doses of γ-irradiation in rat’s bone marrow (BM). Rats were exposed to 8 Gy of γ-irradiation as accumulated doses and subsequently treated with BPF (1μg/g i.p.) aiming at elucidating the possibility of BPF to reduce irradiation harmful effects. The data obtained showed that the irradiated animals suffered from marked changes of many important hematopoietic parameters including red blood cells, white blood cells, platelets, viable bone marrow count, and serum hematopoietic growth factors as well as oxidative stress markers and apoptotic index in BM tissue. Interestingly, BPF was able to rescue the deleterious effects of irradiation in rats and normalized the aforementioned parameters to the basal levels.
In conclusion: The considerable amelioration of hematic morbidity, oxidative stress and apoptosis in BM exhibited new accomplishment to the BPF isolated from bee venom against accumulated irradiation defects.

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