Activation Role of Low Dose Ionizing Radiation on Human Lymphocytes Response

Document Type : Original Article

Authors

Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P. O. Box: 29 Nasr City, Egypt

Abstract

LOW dose ionizing radiation can imitate the role of deteriorate antigen or attenuated microbes as it activates the first defence line of immune response, the step which when lost, cancer cells can find suitable environmental condition for growth propagation. Human whole blood samples were irradiated in vitro at doses (0.25, 0.5, 0.75 and 1Gy) of ionizing radiation and then kept at 37oC for 1h before measuring glucose concentrations which reflect the maximum activation of immune cells. Then, immunological parameters such as interlukine-1β (IL-1β), interlukine-2 (IL-2), transforming growth factor beta (1) (TGF-β1) were investigated. Also, inflammatory mediators as intracellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and tyrosine kinase activity were determined. Low doses of ionizing radiation induced slight activation of the immune cell cytokines (IL-1β and TGF-β1), inflammatory mediators (ICAM, VCAM) and tyrosine kinase activity at doses (0.25, 0.5Gy) reaching to significant levels at 0.75Gy and 1Gy. While, IL-2 and glucose levels were significantly decrease.

Keywords

Egyptian Journal of Radiation Sciences and Applications
Volume 31, Issue 2
December 2018
Pages 89-95

Files

Share

How to cite

Statistics