2024-03-28T19:58:17Z
https://ejrsa.journals.ekb.eg/?_action=export&rf=summon&issue=11290
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Effect of Clodronate Alone or in Combination with Vitamin E on Demineralization Induced by Whole Body Gamma Irradiation in Rats
Heba A.
Gheita
Walaa A.
Elsabbagh
Rania M.
Abdelsalam
Amina S.
Attia
Mona A.
El-Ghazaly
BISPHOSPHONATES usually have been chosen in cancer treatment protocols for the management of fractures risk and controlling metastatic bone pain following chemo- and radiotherapy. This study aims at investigating the beneficial effect of clodronate alone or in combination with vitamin E in irradiated rats exposed to 1Gy 3 alternating days/week for 5 weeks. Calcitonin was also studied individually and in combination with vitamin E in order to investigate its possible effect on bone mass in irradiated rats. Irradiated rats treated with clodronate (5mg/kg, s.c., twice a week) or calcitonin (10 IU/kg, s.c., 48hrs) showed significant decreases in urinary hydroxyproline (Hpr), calcium (Ca) and significant increases in urinary phosphorus (Ph) and serum total antioxidant capacity (TAC) levels, while combination with vitamin E normalized most of measured parameters. It could be concluded that vitamin E could synergize the anti-osteoporotic effect of clodronate or calcitonin especially in γ- irradiated cases.
Clodronate
Calcitonin
Vitamin E
γ- irradiation
2019
12
01
125
136
https://ejrsa.journals.ekb.eg/article_67781_f8f97ee83193ac4d97d9bc723107b48f.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Antioxidant Capacity of Achillea millefolium L. against Cytogenetic and Immunological Disorders in Irradiated Human Blood Cultures
Sherien
Montaser
Mahmoud
Mahmoud
Sahar
Ibrahim
THE POSSIBLE antioxidant role of Achillea millefolium L. (ACM) extract was investigated against mutagenecity and immunological disorders in irradiated human blood cultures. Peripheral blood samples were collected from healthy human volunteers then incubated in the prepared cultures. The whole blood was exposed in vitro to 3 Gy of γ-ray and then the blood was cultured with mitogenic stimulation and ACM extract at different concentrations (100 & 200μg/ml). After 72hr of incubation, cytokinesis-block micronucleus analysis (CBMN) and immunological parameters: Interleukin-8 (IL-8), interleukin-18 (IL-18), cyclooxygenase-2 (COX-2) and tumor necrosis factor (TNF-α) were investigated. At each dose point, the treatment of the blood with ACM showed a significant decrease in the incidences of micronuclei (one, two and three micronuclei). Also, there are amelioration in the levels of IL-8, IL-18, Cox-2 and TNF-α. The maximum protection effect according to the selected parameters was observed at 200μg/ml of ACM extract. The presented data suggested that ACM may play important roles as antimutagenic and antinflammatory protectors against radiation exposure.
Achillea millefolium L
Micronuclei
Inflammatory cytokines, Human blood culture
2019
12
01
137
144
https://ejrsa.journals.ekb.eg/article_44265_0dc9c2cda2febf3a7e1cd345f7e8f619.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Preparation and Quality Control of 113Sn, 125Sb and 60Co Adsorbed in ZrSiW: Volume and Planar Reference Source for -Detector Calibration
Hassan
El-Said
S.
Sharaf El-Deen
Mohamed
Aydia
M.
El-Naggar
Khaled
El-Azony
NEUTRON activation of tin metal and cobalt chloride targets for production of 113Sn and 125Sb and 60Co was carried out in Egypt’s Second Research Reactor (ETRR-2). The 113Sn, 125Sb and 60Co were loaded onto zirconium silicotungestate gel matrix from aqueous solution at pH 1 by the batch technique. The results obtained during the adsorption process of radionuclides were explained through the Visual MINTEQ program version 3. Then 1 and 0.1g of 113Sn. 125Sb and 60Co-ZrSiW were packed into the volume and planar sealed sources, made of Chinese Artelon, respectively. The radioactivity levels of 113Sn, 125Sb and 60Co were measured and found to be (2.96±0.26, 2.22±0.26, 0.74±0.074kBq) and (0.3±0.03, 026±0.03, 0.11±0.01kBq) for the volume and planar sealed source, respectively, on 27 June 2018. The efficiency curves for the two sealed sources were determined in the energy range 36-1332.5keV, which were measured at 5cm from the HPGe-detector to determine the radioactivity levels of unknown samples for the neutron activation method.
Sealed Source
125Sb
113Sn
60Co
Efficiency calibration
2019
12
01
145
154
https://ejrsa.journals.ekb.eg/article_45583_075344801511730542728786aa6cb2a2.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Assessment of Cerebral Collaterals in Acute Ischemic Stroke by CT Cerebral Angiography and Its Relation to the Functional Outcome
Dina
Elessawi
Aymen
Nasf
Ali
Shalash
Dina
El Husseiny
Ebthal
Bakry
THIS STUDY aims at evaluating the relationship between the state of cerebral collateral blood vessels and the functional outcome of patients with acute ischemic stroke with or without thrombolytic therapy. The study was carried out in the inpatient sector of the neurology department at Ain Shams University hospitals. A sample of 30 patients with acute ischemic stroke was collected and CT cerebral angiography was done to assess the clot burden score and the collateral score. MRI stroke protocol was performed to assess the structural collaterals through diffusion weighted image, FLAIR, NIH, and MRS. There was a statistical significant difference between stroke patients who received treatment and patients who did not receive traetment in relation to collateral score, clotting burden score, modified Rankin scale after three months, onset by hours and door to needle. Computed tomography angiography and MRA played an important role in the assessment of the collateral blood vessels, clot burden score, infract volume and also predicted the need for recombinant tissue plasminogen activator (rtPA) and the degree of improvement. There was a significant correlation between the modified Rankin scale and the clotting burden scale, the collateral scale and the infract volume. Patients with good NIH score and MRS show a higher level of improvement. It could be concluded that the collateral status as assessed by CTA is considered an excellent predictor of a favorable functional outcome in acute ischemic stroke patients. Patients with good collateral status will benefit from recanalization and patients with poor collaterals likely will not benefit even when recanalization occurs.
Cerebral collaterals
Acute ischemic stroke
CT cerebral angiography
2019
12
01
155
167
https://ejrsa.journals.ekb.eg/article_47152_a4dacbe3e103444a38d265bfca101860.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Evaluation of C-Reactive Protein and CXCL16 in Acute Coronary Syndrome
Neveen
Nosseir
Phebe
Abdel-Messeih
Ossama
Bakheet
Samer
Abdel Shafy
ACUTE coronary syndrome (ACS) is a life-threatening condition. Diagnosis and follow up depend on clinical examination, electrocardiogram (ECG), positron emission tomography (PET) and biochemical markers. Troponin is significantly used in the diagnosis and prognosis of ACS, however, its increase in absence of ACS prompts an evaluation for an alternative.CXCL16, an interferon γ regulated chemokine, in addition to the fact that it is expressed in atherosclerotic lesion. C-Reactive Protein (CRP) is up regulated in atheromatous plaque. The aim of the present study is to evaluate the importance of measurement of CRP and CXCL16 together with other biochemical markers of myocardial injury in the diagnosis and follow up of ACS.The study included 90 participants, 60 patients of ACS (30 unstable angina and 30 myocardial infarction) and 30 healthy age and sex-matched participants who formed the control group.All patients and controls underwent the following laboratory investigations: Serum aspartate aminotransferase (AST), creatine kinase muscle band (CK MB), lactate dehydrogenase (LDH), troponin and CXCL16 by ELISA and CRP by Nephelometry. The mean values of CXCL16, CRP, AST, CK MB, LDH were highly elevated in ACS, while troponindid not significantly elevated in unstable angina patients compared to the controls. A significant positive correlation was found between CXCL16 and both CRP (r2= 0.89) and troponin (r2= 0.93) in myocardial infarction patients. It is concluded that CRP, and CXCL16 may be additional tools for the diagnosis and prognosis of ACS besides other biochemical markers.
CRP
CXCL16
Acute Coronary Syndrome
2019
12
01
169
175
https://ejrsa.journals.ekb.eg/article_52550_4444bb9155d11f740d4432cf22e1edea.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Oxidative Stress Parameters in Patients with Breast Cancer before and after Radiotherapy
Hanan
Youssef
Hala
Salem
REACTIVE oxygen species (ROS) are generated in response to endogenous or exogenous stimuli. Antioxidants defense system resists for balancing ROS-mediated injury; if oxidation exceeds the defense mechanisms, oxidative stress is generated. Oxidative stress may be involved in the development of breast cancer. Moreover, radiationtherapy (RT), used for the treatment of breast cancer, works by the production of reactive oxygen species at the site of radiation which leads to local oxidative stress. Studies which detect one or few oxidant and antioxidant markers failed to detect the overall oxidant/antioxidant status of the subjects. The authors aim at studying the impact of radiotherapy on the total oxidant status (TOS), total antioxidant status (TAS) with calculation of oxidative stress index (OSI), and measure the lipid peroxidation (MDA) in breast cancer patients.TAS, TOS, MDA and OSI in healthy and breast cancer groups are measured. In breast cancer group, all parameters were measuredbefore and after radiation therapy.In the breast cancer group, TOS, OSI and MDA levels have increased significantly (P<0.001) and the TAS level has decreased (P<0.001) in the breast cancer patients after radiotherapy than before radiotherapy. Breast cancer group TAS after RT reaches about forth its level measured inthe control group. Radiotherapy in breast cancer patients depletes the total antioxidants (TAS), increases total oxidative status (TOS), lipid peroxidation (MDA) and OSI. Breast cancer and its treatment modalities display the patients in a state of severe oxidative stress which requires the supplementation of antioxidants.
Cancer breast
Radiotherapy
TOS
TAS
MDA
2019
12
01
177
185
https://ejrsa.journals.ekb.eg/article_54302_3140e701bbcc9bdd38c58932c0169397.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Efficiency of Kumquat Fruit ( Fortunella margarita ) Extract against Hepatotoxicity and Infertility Induced by Gamma Irradiation in Male Albino Rats
Inas Z.A.
Abdallah
M.M.
Ahmed
S.A.
Montaser
Salwa S.
Hafez
Ionizing radiation (IR) generate reactive oxygen species (ROS). Imbalance between ROS and antioxidants level leads to oxidative stress. Fortunella margarita (F. magarita) fruit contains a lot of bioactive compounds, such as polysaccharides, flavonoids, phenolic acids, ..etc. So it has high radical scavenging capacities and strong antioxidant activity. This study was designed to determine the probable efficiency of F. margarita extract against liver damage and sperm abnormalities induced by γ-radiation in male rats. Thirty six rats were divided into 6 groups (6 rats each): control group, treated groups: 14 days F. margarita group and 28 days F. margarita group, irradiated group (Irr): rats were exposed to 6Gy of whole body γ-radiation, pre-treated (14 days F. margarita extract + Irr) group and pre- and post- treated (28 days F. margarita extract + Irr) group. Biochemical investigations: lipid profile: total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C). Liver function enzymes: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) level, hepatic tissue malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione reduced (GSH) levels. Fertility competence: (sperm head, tail and head and tail abnormalities) were recorded. Results obtained revealed the strong efficiency role of F. margarita fruit extract as an antioxidant against hepatotoxicity through enhancement of liver function ( ALT, AST and GGt) , reduce oxidative stress ( MDA, SOD and GSH), and powerful recovering of sperm abnormalities induced by γ-irradiation also it shows adjusting and normalize (TC, HDL-C, LDL-C, VLDL-C and TG).
Fortunella margarita
γ-radiation
Lipid profile
Hepatotoxicity
Infertility
2019
12
01
187
199
https://ejrsa.journals.ekb.eg/article_60767_bf4fd5124616fdb9d2f63bec44906d18.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Role of Asymmetric Dimethylarginine and Nitric Oxidein Type 2 Diabetes Mellitus and its Cardiovascular Complications
Manal
Alkady
Iman
Ibrahim
AN ENDOGENOUS inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (T2DM) and has been related to atherosclerotic disease. The study aims at investigating the status of ADMA and nitric oxide (NO) and their possible correlation inpatients with T2DM with and without cardiovascular complicationsin comparison to normalcontrols. Forty patients with T2DM and 20 age, sex and body mass index (BMI)‑matched healthy controls were included in the study. The studied individuals were divided into Group1: healthy controls (n= 20), Group 2: T2DM patients without cardiovascular complications (n= 20) and Group 3: T2DM patients with evidence of cardiovascular complications (n= 20). Serum ADMA levels were determined by enzyme linked Immunosorbent Assay (ELISA). Serum nitric oxide was measured as stable end product, nitrite. Insulin was measured by immunoradiometric method. Serum ADMA levels showed a significant elevation while serum NO levels were significantly reducedin diabetic patients groups in comparison to controls. Diabetic patients with vascular complications showed highly significant increase in ADMA levels and pronounced decrease in NO compared to those without complications. In the group of vascular complications, the ADMA level was positively correlated with postprandial serum glucose and HbA1c, but there was a negative correlation between ADMA levels and NO. ADMA and NO may serve as predictors for future cardiovascular events in T2DM patients. Further studies are required to establish the utility of decreasing ADMA levels or increasing NO in the management of T2DM patients.
Asymmetric dimethylarginine
Type 2 diabetes mellitus
Nitric oxide
Cardiovascular complications
2019
12
01
201
210
https://ejrsa.journals.ekb.eg/article_54710_34c4639ccbe494b43a4263309d85bc52.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Agreements between CT, Intra-operative Inspection and Pathology Regarding Staging Local Cancer Colon
Eman
Sabek
Gihan
Saleh
Ehab
El-esseily
Colorectal carcinoma is the most common gastrointestinal malignancy, accurate staging is very important for proper treatment, Continuous advances in CT machines, continuous change in disease process and its pathogenicity will change the accuracy of this modality and weather it can be relied on in local staging. Our aim is to evaluate the accuracy of contrast enhanced computed tomography (CT) in local staging of colorectal cancer by comparing it to operative findings and whether surgeon can depend on its results in planning surgery, also comparing CT and intraoperative results to pathology reports. so we can see the strength points and weakness points of CT regarding macroscopic eye inspection and compare it to microscopic pathologic way. Results regarding the T-staging, the CT accurately diagnosed 83 cases correctly, while the intraoperative examination of the specimen diagnosed only 81 cases correctly, a difference which is not statistically significant, regarding N stage, the intraoperative examination was more accurate than the CT as it correctly diagnosed 61 cases while the CT diagnosed only 56 cases correctly, a difference which is also not statistically significant. Our conclusion is that CT is an accurate method in staging regarding stage III and IV, the accuracy is still not reliable in stage I and II. Regarding N- staging system CT has low accuracy regarding pathology, this accuracy increases if compared with operative data.
Colon cancer
Local staging
MDCT
2019
12
01
211
218
https://ejrsa.journals.ekb.eg/article_64860_5b10f83da2c994074228d6f641156dc0.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Ameliorative Effect of Sugarcane (Blackstrap) Molasses Against Gamma Radiation or Manganese- Induced Testicular Toxicity in Male Albino Rats
Nadia
Abdelmagid
Nahed
Abdel aziz
Shereen
Shedid
Amal
Ahmed
SUGARCANE molasses is a potent antioxidant. Radiation and excess manganese are toxins causing a wide range of adverse effects that can be severe and induce tissues damage to mammals. In an attempt to minimize these effects, the present study aims to evaluate the mitigating effect of molasses on radiation or manganese toxicity-induced testicular tissue damage. Rats were whole-body gamma-irradiated with a single dose of 6Gy, or administered MnCl2 4H2O in a single intraperitoneal injection (100mg/kg body weight). The results showed that molasses treatment (200mg/ 100g body weight/day) for seven days post-radiation or manganese toxicity induced a marked amelioration in the oxidative stress biomarkers of serum and testicular tissues of rats manifested by decreased levels of total nitrate/nitrite (NOx) and malondialdehyde (MDA) associated with an elevation in the total antioxidant capacity (TAC). Molasses treatment has induced also a significant elevation in the mitochondrial cytochrome c oxidase (COX). Marked improvement in the level of serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and glucose was also observed. Moreover, molasses was effective in modulating the concentration levels of copper (Cu), iron (Fe), zinc (Zn), manganese (Mn) and selenium (Se) in testicular tissue and epididymis. Additionally, the epididymal sperm count, as well as motility and viability percentage had markedly increased in rats treated with molasses, whereas there was a significant decrease in the number of sperms with abnormal morphology. In conclusion, sugarcane molasses can be considered as a new natural mitigating agent on the testicular injury induced by radiation or Mn-toxicity.
Oxidative Stress
Mitigators
Radiation
Manganese toxicity
Sugarcane
Testicular tissue
2019
12
01
219
233
https://ejrsa.journals.ekb.eg/article_65322_4e07b6d0580d60473ece90392650e034.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Effect of Gamma-Radiation on Hygienic Quality, Amino Acids and Antioxidant Eenzymes in Beef Meat and Liver
Wafaa
Sayed
Dalia
Khater
Fatma
Eldemerdash
Madeha
Ibrahim
IN THE PRESENT study, the effect of different doses of gamma irradiation (1, 3, 5 and 7kGy) on the hygienic quality (microbial and sensory properties) as well as antioxidant parameters in beef meat and liver were investigated. The microbial reduction increases as the dose level of irradiation increases. Sensory examination revealed that there were no significant changes between irradiated and non-irradiated groups in color, odor and texture. Results showed that the changes in protein profile depended on radiation dose while the total protein content was stable. In addition, irradiation treatment reduced the activity of the antioxidant enzymes as well as glutathione content.It could be concluded that the use of gamma irradiation in low doses improves the hygienic quality of beef meat and liver without changing its chemical parameters while oxidative stress and enzymatic and non-enzymatic antioxidants are affected in a dose-dependent manner.It is highly recommended that gamma irradiation (3kGy) in low doses could be used to improve the hygienic quality of liver and meat.
Beef-meat
Beef-liver
γ-rays
Sensory-evaluation
Amino-acids
Oxidative-stress
Antioxidant-enzymes
2019
12
01
235
244
https://ejrsa.journals.ekb.eg/article_66889_8dca61f3512993e7ed88c81618e06299.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2019
32
2
Improving Minced Meat Quality by Edible Antimicrobial Polymers and Gamma Radiation
Wafaa
Sayed
Magda
El-Banna
Madyha
Ibrahim
THE HYGIENIC quality of minced meat preserved by dipping in edible antimicrobial polymers was evaluated and compared with exposure to gamma-radiation. Solutions of Carboxymethylcellulose incorporated with zinc oxide (CMC/ ZnO), polycarbonate/ zinc oxide (PC/ ZnO) and chitosan (CS) were prepared and applied to 3 minced meat groups compared to an irradiated group at 3kGy γ-rays. The results indicated that dipping minced meat in polymers improved its microbiological, chemical and sensory hygienic quality. Control samples (dipped in distilled water) were rejected hygienically on the seventh day. Sensory property scores revealed improvement in color, odor and texture of polymer treated and irradiated meat samples and remained acceptable till the end of storage period. Sensitivity test conducted using the films of the prepared polymers revealed that Staph. aureus was only sensitive to CMC, but it was not sensitive to other polymers. List. monocyt. was more sensitive to CS, which showed no sensitivity to other polymers. Candida albicans was sensitive only to CMC. It could be concluded that antimicrobial polymers and irradiation at 3kGy γ-rays improved the quality parameters of minced meat and could be used in food preservation as it increased the chilling-life of minced meat.
Minced meat
Antimicrobial polymers
Hygienic quality
Sensory evaluation
Food microorganisms
2019
12
01
245
253
https://ejrsa.journals.ekb.eg/article_67034_54734672d485af90716db77c18b4bae6.pdf