2024-03-28T22:13:17Z
https://ejrsa.journals.ekb.eg/?_action=export&rf=summon&issue=331
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2016
29
1
Anti-inflammatory and Anti-nociceptive Effects of piperine in Gamma-irradiated Rats
PIPERINE is an alkaloid that is found naturally in plants belonging to the piperaceae family and has been reported to possess anti-inflammatory properties. The present study was constructed to investigate the possible anti-inflammatory and analgesic effects of piperine on different inflammatory models induced in irradiated rats. Paw volume and nociceptive threshold were measured in carrageenan-induced paw oedema and hyperalgesia model. Leukocytes count, tumour necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), thiobarbituric acid reactive substances (TBARs) and total nitrate/nitrite (NOx) were estimated in the exudate collected from six-day old air pouch model. Irradiated rats were exposed to 6Gy gamma (γ)-irradiation. Oral administration of piperine at a dose of 50mg/ kg resulted in a significant decrement in the paw volume and significant increment in the nociceptive threshold, in non-irradiated and irradiated rats. The inflammation induced in irradiated rats in the six-day old air pouch model increased all the estimated parameters in the exudate whereas; piperine decreased their elevation in non-irradiated and irradiated rats. Piperine possesses a potential anti-inflammatory and anti-nociceptive activity on inflammation induced in irradiated rats.
Inflammation
gamma-irradiation
Piperine
Carrageenan
air pouch
2016
12
31
1
16
https://ejrsa.journals.ekb.eg/article_1575_e36e369652ac9ea53f99d697706e2e8d.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2016
29
1
The Potential Therapeutic Effect of Ferulic Acid in Mitigating Oxidative Stress Induced by γ-Irradiation in Male Rats
THE TESTIS is considered as one of the most sensitive organs in the body to ionizing radiation because of the rapidly dividing germinal epithelium. Seminal oxidative stress (OS) causes damage of the sperm plasma membrane and loss of its DNA integrity, therefore, the need for an effective therapeutic agent is evident. The present study investigated the mechanism(s) of potential therapeutic effect of ferulic acid (FA) on radiation-induced testicular damage.
Mature male albino rats were either exposed to single dose γ-radiation (5Gy) and/ or treated with FA (50mg/ kg body wt, orally), daily for seven days post-irradiation. FA significantly reversed OS effects of γ-rays that was evidenced by increasing malondialdehyde (MDA) and decreasing ferric reducing antioxidant power (FRAP) and catalase (CAT) activity. In addition, alterations in some trace elements such as zinc (Zn), cupper (Cu), iron (Fe) and manganese (Mn) were observed. Furthermore, sperm head abnormalities noticeably increased in the γ-irradiated group; in contrast, FA treatment ameliorated these alterations.
In conclusion, FA exhibited curative effect against radiation induced testicular damage.
ferulic acid
γ-rays
Oxidative Stress
trace elements
testes
2016
12
31
17
31
https://ejrsa.journals.ekb.eg/article_1576_c80a5c6082675719dbd98dacce6e6277.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2016
29
1
Glutathione Enhancer Protects Some Biochemical and Haematological Parameters from the Effect of Electromagnetic Field
THE PRESENT study was designed to study the effect of exposure to electromagnetic field (EMF), emitted from a cellular tower for mobile phone on some biochemical and haematological parameters in male albino rats and to evaluate of the possible protective role of the antioxidant glutathione enhancer on the studied parameters.
Three groups of rats were studied, the control (unexposed), the exposed and the treated exposed groups. Exposed groups were subjected to EMF at frequency of 900MHz, with a peak power of about 60W, power density of 0.05mW/ cm
2 at the site of exposure for 24h/ day for 8weeks, at the same time treated group was supplied with oral injection of glutathione enhancer three times weekly.
At the end of experiment, serum levels of thyroid stimulating hormone (TSH), calcium (Ca), uric acid, malondialdehyde (MDA) beside, the activity of lactate dehydrogenase (LDH) were measured also, some haematological parameters were estimated. Impairment of TSH and serum calcium was expressed by a decrease in serum levels of the exposed group. Meanwhile, serum level of MDA, uric acid and the activity of LDH were increased by exposure.
The haematological studies revealed that, exposure to electromagnetic spectrum induced significant reduction in red blood cell counts (RBC's), and haemoglobin concentration (Hb), meanwhile reticulocyte count (Ret) was elevated.
The leucocyte counts (WBC's) and platelets count were not affected by exposure.
The study demonstrated that glutathione enhancer can attenuate the side effects of exposure to electromagnetic field.
Electromagnetic radiation
biological parameters
antioxidants
2016
12
31
33
48
https://ejrsa.journals.ekb.eg/article_1577_c3558c3f796ae3411019838fd299e388.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2016
29
1
Preparation of Sandy Soil Stabilizer for Roads Based on Radiation Modified Polymer Composite
RADIATION modified polymer composite (RMPC) was studied to build an extremely durable sandy road, construct a trail or bath, or control dust and erosion. A dilute solution of composite binds sandy soil fines through a coagulation bonding process.
The result is a dense soil structure that has superior resistance to cracks and water penetration and can also solve erosion control problems. In erosion control applications, diluted composite is merely sprayed into sandy soil without compaction, effectively sealing the surface to prevent air-born dust or deterioration from erosion.
The prepared composite has an elastic and melt-able film formation that imparts thermal compacting to the stabilized sandy soil after full dryness for sandy road leveling, repairing and restoration processes. The prepared composite is environmentally economical when compared with traditional sandy soil stabilizing (SSS) or sealing methods.
Sandy soil stabilizer
Composite
Radiation
2016
12
31
49
62
https://ejrsa.journals.ekb.eg/article_1578_0106eaaf41d4292a41a676255eb44fd5.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2016
29
1
Possible Using of Tetra Bromo Phenol Phthalein Ethyl Ester as a Liquid Dosimeter
AQUEOUS SOLUTION of pH indicator Tetrabromo phenol phthalein ethyl ester (TBPE) containing of chloral hydrate was studied for using as a liquid dosimeter.
The useful measuring range was found to be of (0.5-2kGy) depending on concentration of both dye and chloral hydrate added.
The dosimeter has good stability before and after irradiation under different storage conditions. Comparison study between direct irradiation of TBPE containing chloral hydrate and back titration of TBPE through irradiation of chloral hydrate was investigated.
Tetrabromo phenol phthalein ethyl ester (TBPE)
back titration
2016
12
31
63
73
https://ejrsa.journals.ekb.eg/article_1579_7463bb80f8fd1e845476f80846312545.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2016
29
1
Physical Study Comparison of Neutral Red dye Prepared by Different Techniques for Low Dose Monitor Application
Investigation of different preparation techniques related to pH indicator; Neutral Red (NR) dye indicates the effect of the substrate on the dose response. NR was incorporated in poly (vinyl alcohol) (PVA) to prepare a thin film dosimeter and added a gelatine to prepare gelatine gel dosimeter. Upon γ-ray exposure, both systems undergo visual red colour bleaching at 485nm for the film and 480nm for the gel at different rates depending on the sensitivity of each system. These two dosimetry systems depend mainly on the polymer substrate base. The useful dose range was up to 30kGy for thin film and 500Gy for gel form.
Neutral red film
gel dosimeter
gamma-rays
2016
12
31
75
84
https://ejrsa.journals.ekb.eg/article_1580_25cb447079ee06dee336b1e6a3fede04.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2016
29
1
Genetic Variant Detected by RAPD-PCR and ISSR in Catharanthus roseus (L.) Cells Exposed to Low Doses of Gamma Rays
CATHARANTHUS ROSEUS (L.) (C. roseus) 10 samples, genetically different of irradiated and control cell suspension culture were detected by both random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) and inter simple sequence repeat (ISSR). The RAPD-PCR and ISSR-PCR profiles were used for building phenetic trees by using Totallab Quant software, showing similarity in the topology of the trees. Both dendograms presented three major clusters that 10 samples irradiated and control, according to genetic similarity.
The control and the irradiated samples at 2.5 and 4Gy, which are highly in the similarity index recorded as 0.101, while the lowest similarity index recorded was 0.058, which was observed between 3.5 and 4.5Gy.
A dendrogram RAPD-PCR for the genetic relationships among the 10 samples irradiated and control of
C. roseus the cell suspension culture taxa was carried out. The 10 samples irradiated and control from C. roseus cell suspension culture taxa were separated into three clusters; cluster one included 1, 1.5, 2 & 3Gy, while the cluster two included control, 2, 2.5, 3.5, 4 & 4.5Gy. The cluster three included 4.5 & 5Gy.
The best doses of gamma rays were from 0.5 to 5Gy in order to
C. roseus cells genome manipulation and induced mutations. The genome modification was the stimulation of the gene expression changes in order to changes of physiological cell and production of cell lines. The aim of the production cell lines to elicit cells enjoys the attributes of high productivity, secondary products, which are used in widely used in the pharmaceutical industry.
Catharanthus roseus (L.)
genetic variant
RAPD
ISSR
PCR
γ rays
cell culture
2016
12
31
85
101
https://ejrsa.journals.ekb.eg/article_1581_6e3bb88170b5718d845e4bb069983b8b.pdf