2024-03-28T14:16:40Z
https://ejrsa.journals.ekb.eg/?_action=export&rf=summon&issue=768
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Ameliorating Effects of Bone Marrow Transplantation and Zinc Supplementation on Physiological and Immunological Changes in γ-Irradiated Rats.
Omaima M.
Ashry
The present study was carried out to determine the prophylactic impact of zinc sulphate administration to irradiated rats treated with bone marrow transplantation (BMT) as indicated by the hematological and immunologic response as well as oxidative stress. Rats were injected orally with zinc sulphate, 10 mg/ Kg body wt, daily for 2 weeks before whole body 5Gy gamma irradiation and intravenous injection of bone marrow cells, one hour post irradiation. The results revealed a significant decrease in red blood cells (RBC), white blood cells (WBC), glutathione (GSH) and zinc superoxide dismutase (Zn /SOD), splenocyte count as well as bone marrow lymphocyte count and viability of irradiated rats. Regarding immunological data: tumor necrosis factor alpha (TNF-α) and interleukin 2 (IL-2) recorded a significant decrease while interleukin 6 (IL-6) and lipid peroxidation product (MDA) in the serum and spleen were conversely elevated. Zn supplementation before irradiation and BMT and showed significant decrease of serum and tissue MDA compared to the irradiated group. Lymphocytes, bone marrow viability percentage, splenocytes percentage, IL-2, IL-6 and GSH were significantly elevated compared to irradiated group. Conclusion: Protection with Zn, enforcing significant innate response, could trigger and augment adaptive immune response by BMT which suggests its use to protect against radiation hazards.
Gamma Irradiation
Zinc Sulphate
immunologic response
2017
12
01
1
10
https://ejrsa.journals.ekb.eg/article_3495_86b38e610eca276c7e02ffb2b2dc04a4.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
The protective effect of Catechin and Rutin on cigarette smoke extract-induced injury in irradiated rats
Mona
El-Ghazaly
Aliaa
Ashoub
Nour El-Din
Mohamed
Sanaa
Kenawy
The present study was designed to investigate the possible protective effects of catechin and rutin and their possible mechanisms of action in guarding against the oxidative stress and inflammation induced by ionizing radiation and/or cigarette smoke extract in rats. Exposure of rats to acute doses of γ-radiation or administration of cigarette smoke extract (CSE) in this study were found to exert an oxidative stress due to generation of ROS, which are characterized by elevation in MDA and nitric oxide levels and depletion in reduced glutathione, as well as elevation in MPO activity and level of TNF-α. The results also showed that activities of ALT, AST, ALP, and LDH were increased. Damaging effects were significantly increased in animals exposed to gamma radiation combined with administration of cigarette smoke extract in comparison to either irradiation or administration of cigarette smoke extract. Pretreatment with catechin or rutin largely protected against the change in all the measured parameters. Conclusion: Catechin and rutin might have the potential to modulate the damage induced by radiation exposure in cigarette smoke-treated animals.
γ-radiation
cigarette smoke extract
catechin
Rutin
Oxidative Stress
2017
12
01
11
21
https://ejrsa.journals.ekb.eg/article_3496_f87ed62cf4f6c0d7c4bf6afd5ab7fc4c.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Multifactorial Elements Affecting Bone Mineral Status and Growth in Children with Thalassemia Major
Eithar
El-Adham
Aim: To determine the association of adipokynes like Leptin, Ghrelin, antioxidants as SOD, Glutathione, peroxidase and iron overload and their effect on growth and on bone mineral density in patients with thalassemia majorMethods: 30 patients and 30 healthy age and sex matched controls from the hematology clinic hospital, Cairo University. Clinical examination and the anthropometric measurements are done in all subjects. Bone mineral density is assessed using DXA machine on lumbar spine expressed in Z Score Laboratory investigations, including super oxide dismutase (SOD) and Glutathione peroxidase.Results: The study showed that there was a significant difference between cases and controls regarding BMI, Leptin, Ghrelin, BMD, SOD and glutathione peroxides with p- values 0.003,
beta thalassemia
leptin
ghrelin
antioxidants
BMD
2017
12
01
23
33
https://ejrsa.journals.ekb.eg/article_3190_6f9db179873f90fbfc5bb3c4c68a27d4.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Electrical Conduction and mechanical properties of irradiated clay nanoparticles /SBR rubber composites
Ahmed
Sadda
Mohamed
Medany
Mohamed
Atta
Styrene butadiene Rubber (SBR) containing Surface Modified Nano particles Clay by Electron Beam Radiation dose 100 KGy (SMEB) and non-modified Nano particles Clay were prepared. Direct current measurements were established for knowing the conduction type of charge transport passing through the modified (SMEB) and unmodified SBR/clay composite samples. Where, it is deduced that Poole-Frenkel conduction mechanism was found to be predominate for all clay-SBR samples. The mechanical Tensile strength and elongation at break were estimated from stress strain curves measured and we realize the tensile strength of SBR matrix increases appreciably with clay loading up to 15 phr, the polymer-filler interaction for modified clay loaded samples is improved slightly higher than unmodified clay samples and From calculations of the slope of the Vro/Vrf versus C/ (1-C) plot. The slop value is founded to be positive which mean that reinforcing by filler having good polymer-filler interaction. Elongation at break increases slightly with clay loading up to 10 phr and then abrupt decrease is detected at 15 phr clay loading for all samples.
Nano composites
SBR
DC properties
Mechanical Properties
2017
12
01
35
44
https://ejrsa.journals.ekb.eg/article_3707_7614306afaa1d8f1a69003a33dda589d.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Screening for Prostate Specific Antigen in Various Types of Breast Tumor
Ahmed
El-Bayoumy
Marwa
Fawzy
Abdel-Rahman
Abdel-Ghaffar
Ahmed
Osman
The objective of the present study was to investigate a comparative estimation screening method of prostate specific antigen levels in serum samples with immunohistochemistry results for analysis expression of prostate specific antigen in female breast tissues at benign breast hyperplasia and breast cancer. This study was applied on 65 women suffering from breast cancer, 31 of them have benign breast hyperplasia and 34 have malignant breast cancer. Each group was divided into 2 subgroups, pre and postmenopause, both subgroups were compared with 15 normal cases to assess serum and tissue PSA in benign and malignant patients in pre and post menopause state by immunoradiometric assay in blood and immunohistochemistry in tissue. No significant difference in serum Total PSA concentration between any of the studied cases. However, there were different variations in the distribution of PSA in the breast tumor tissue, with complete absence of PSA in the tissue samples of the malignant in postmenopausal patients. In conclusion, PSA presence in benign breast hyperplasia in either serum or tissue may show clinical value regarding the diagnosis and prognosis of the disease.
prostate specific antigen
Breast Tumor
CA 15-3
Immunohistochemistry
2017
12
01
45
52
https://ejrsa.journals.ekb.eg/article_3706_21d0b14f796f14ee6b8b0b7c1ce44ec4.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Identification of the Therapeutic Effects of Gamma-Irradiated Chamomile Aqueous Extract Against Alcohol Induced Hepato-nephrotoxicity in Rats
Mohamed
Abd el-Megid
A.
Abdul Azeem
A.
el-Shahat
H.
Mekawey
Alcohol consumption represents the third largest risk factor for disease burden in most countries of the world and can damage several organs and systems in the body such as liver and kidney. Medicinal herb plants may act as an effective remedy for the enormous health burden posed by alcohol consumption. The aim of this study was to investigate the therapeutic effects of an aqueous extract of gamma-irradiated chamomile (GCE) (10 kGy) on alcohol-induced hepato-nephrotoxicity in rats. In this study, results of rats that received alcohol alone (1 ml of 70 % ethanol daily for 56 days) showed hepato-nephrotoxicity as indicated by significant increases in the activity of hepatic enzyme markers. These changes include: increased levels of serum creatinine, urea and uric acid with significant decreased levels of total protein, albumin and globulin. Ethanol administration also resulted in elevation in malondialdehyde (MDA) concentration and the activity of xanthine oxidase (XO) and alcohol dehydrogenase (ADH) with reduction in glutathione level (GSH) and the activities of aldehyde dehydrogenase (ALDH) , xanthine dehydrogenase(XDH),superoxide dismutase(SOD) and catalase (CAT) in both liver and kidney tissues compared to control rats. Post-treatment of ethanol-administered rats with aqueous gamma-irradiated chamomile extract significantly ameliorates the deleterious effects of ethanol on all biochemical parameters and enhances the hepato-renal antioxidant status and improved alterations in hepatic alcohol metabolizing enzymes. Conclusion: Thus, gamma-irradiated chamomile can be suggested to offer distinct treatment against ethanol induced organ damage.
Key words: Chamomile
Alcohol
Hepatotoxicity
Nephrotoxicity
gamma-irradiation
2017
12
01
53
61
https://ejrsa.journals.ekb.eg/article_4467_ce7c7823ad33e4b9b5a33f34bab8a9a1.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Vitamin D Assessment In Iron Deficiency Anemic Pregnant Women and Their Newborns
Elham
Marei
Dina
ُElmaghraby
Alia
Gad
: Vitamin D is a prohormone nutrient, which is involved in skeletal and extra-skeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells and oxygen transport. This element plays important roles in enzymatic systems including those required for Vitamin D activation. Iron deficiency anemia (IDA) is one of the most common diseases among pregnant women worldwide. Vitamin D deficiency (VDD) during pregnancy might be associated with some adverse effects on fetal growth. This study was designed to assess the possible relationship between IDA in pregnant mothers, their corresponding newborns and vitamin D deficiency (VDD). Research Design and Methods: Maternal and fetal serum25-hydroxy vitamin D levels were evaluated using radioimmunoassay (RIA) technique, in 25 pregnancies with IDA compared to 15 age-matched uncomplicated term gestations. Birth weight and clinical status of the neonates were assessed. Results: The present study revealed that 25-hydroxy vitamin D level was statistically decrease in IDA pregnant group in comparison to the control group (p
Vitamin D Assessment In
2017
12
01
63
72
https://ejrsa.journals.ekb.eg/article_3708_13e7a16cbcfcc54bba5151aa369fc05e.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Role of Annona muricata (L.) in oxidative stress and metabolic variations in diabetic and gamma-irradiated rats
Mina
Kamal
Ehab
Mohamed
El-Sayed
Mahdy
Gamal
Singer
Shereen
Elkiki
A. muricata L., commonly known as graviola, is a plant widely distributed throughout the world rich in phytochemicals and minerals. The objective of this study was to investigate the influence of A.muricata on oxidative stress in the liver, kidney and pancreas along with variations in glucose, insulin, lipid profile, liver and kidney functions in diabetic (DM) and γ-irradiated rats (IRR). Diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg/Kg body weight). Irradiation was performed as whole body γ-irradiation (5 Gy) administered in a single acute dose. A.muricata leaves aqueous extract (100 mg/Kg body weight) was administered via gavages during 2 weeks to diabetic rats or during 2 weeks before γ-irradiation. Diabetic rats received A. muricata during 2 weeks before irradiation. Animals were sacrificed 24 hours post irradiation and/or A. muricata trearment. A. muricata treatment has significantly attenuated hyperglycemia, hypoinsulinemia and dyslipidemia, and reduced the increase of serum alanine and aspartate amino transferase activities and serum urea and creatinine levels. The amelioration in metabolic variations was associated to significant improvement of oxidative stress in tissues notified by a higher superoxide dismutase (SOD) activity and glutathione (GSH) content and a lower malondialdehyde (MDA) content. It could be suggested that the synergistic relationship between the different elements found in the leaf of A.muricata could be beneficial in ameliorating liver and kidney function and correcting metabolic variations associated with oxidative stress in the liver, kidney and pancreas.
diabetes
streptozotocin
γ-irradiation
A.muricata
Oxidative Stress
metabolic variations
2017
12
01
73
83
https://ejrsa.journals.ekb.eg/article_3679_3ac17429dd15b84b1e82c67bf326cc79.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Vitamin D Level in Breast Cancer Premenopausal Patients before and after Adjuvant Therapy
Hanan
Gabr
ُElham
Marei
Many factors have been claimed to increase breast cancer risk; as age at menarche and menopause, hormonal exposures, previous benign breast lesions, family history of breast cancer, exposure to ionizing radiation, smoking and alcohol. Researches claimed vitamin D deficiency as the cause of multiple diseases, including cancer. Perhaps its deficiency upregulates the hormonal and genetic predisposition of the patients and there is still a need for investigating more factors for breast cancer etiology and therapy. Sources of vitamin D are sunlight exposure or diet and dietary supplements. The aim of this study was to demonstrate vitamin D status in breast cancer patients at diagnosis, and weather this level changed with chemotherapy and radiotherapy. This case control prospective study was carried out on 40 premenopausal patients diagnosed as breast cancer patients and 20 healthy women in whom serum hydroxy vitamin D (25OHD) levels were analyzed at the beginning of study, and after chemotherapy and radiotherapy. The data revealed that mean serum vitamin D concentration in healthy control group was (22.35 ± 5.92 ng/ml), which considered insufficient. Patients at diagnosis were vitamin D deficient with mean level (16.77±1.96 ng/ml); then after receiving adjuvant therapy in the form of chemotherapy and radiotherapy, vitamin D mean level was (11.70±3.08 ng/ml); i.e. the mean level decrease by 30.23%. It could be concluded that breast cancer patients had lower vitamin D levels than the age matched control women. Vitamin D in breast cancer patients decreased more after chemotherapy and radiotherapy.
Vitamin D
breast cancer
Chemoradiotherapy
2017
12
01
85
93
https://ejrsa.journals.ekb.eg/article_4480_f0f99c4426b4e649399eaa636abc942b.pdf
Egyptian Journal of Radiation Sciences and Applications
Egypt. J. Rad.Sci.
1110-0303
1110-0303
2017
30
1
Dielectric properties, Impedance analysis, and electrical conductivity of Ag doped radiation grafted polypropylene
Lobna
Abd El-Wahab
Amr
El-Hag Ali
The possibility of obtaining relatively high dielectric constant polymer-metal composite by incorporating silver nanoparticles in a polypropylene (PP) polymer matrix by grafting and successive reduction method was demonstrated. Frequency and temperature dependence of AC conductivity and dielectric constant (ε') and dielectric loss (ε'') in pure polypropylene, PP-g-(AAc-co-Sty), and PP-g-(AAc-co-Sty)-Ag nanocomposite are studied in the frequency range 50 Hz- 5 MHz and in the temperature range 30- 70 oC. The experimental results show that the polarity of PP is weak due to deficiency of polar groups. The values of ε' and ε'' increased dramatically with the addition of silver nanoparticles in polypropylene. The obtained AC conductivity is follow the correlated barrier-hopping model (CBH) since the frequency exponent (s) and AC conductivity are both frequency and temperature dependent. The calculated value of maximum barrier height Wm for PP-g-(AAc-co-Sty)-Ag is 0.242eV. The dielectric relaxation process are studied in respect of the electric modulus formalism.
grafting
polypropylene
Nanocomposite
Silver nanoparticles
impedance
Electric modulus
2017
12
01
95
107
https://ejrsa.journals.ekb.eg/article_4641_93e0722d2cda8e61d9831d620af7fae0.pdf