Recovery Role of Genistein in Modulating the Alterations in Some Haematological Parameters and Hepatic Antioxidant Enzymes in Gamma Irradiated Mice

doi:10.21608/ejrsa.2011.1450

Recovery Role of Genistein in Modulating the Alterations in Some Haematological Parameters and Hepatic Antioxidant Enzymes in Gamma Irradiated Mice

Document Type : Original Article

10.21608/ejrsa.2011.1450

Abstract

GENISTEIN; 4',5,7-trihydroxy-isoflavone (C15H10O5) is an antioxidant nutrient, generally considered as a protective agent. The objective of this work is to study the radio recovery role of genistein in mitigating γ-rays induced injury to the liver and alterations in some haematological parameters of adult male mice. Genistein (150 mg/ kg body wt) was administrated to mice, once daily for 7 consecutive days before whole-body (4.5Gy) γ-rays-exposure then continued for 7 days after exposure..
The results showed that genistein significantly elevated liver catalase (CAT) and glutathione peroxidase (GPx) enzyme activities and decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity. Genistein treatment also, accelerated the recovery of circulating white blood cells (WBCs) and reticulocytes (RETs) counts throughout the experimental time. On the other hand, genistein failed in recovering the red blood cells (RBCs) count. Conclusion: Genistein has significant radio recovery task in γ-irradiated mice.

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