Radio-adaptive Response: An Implication for the Biological Consequences of Low Dose-rate Exposure to X-Ray

Document Type : Original Article

Abstract

 RADIATION induced adaptive response is described as the reduced damaging effect of a challenging radiation dose when induced by a previous low priming dose. To verify the radio-adaptive response that can be induced by occupationally (in vivo) received chronic low dose of X-ray, chromosomal aberration (CA) analysis, micronucleus test (MN), interleukin-1β (IL-1β) and nitric oxide (NO) concentrations were investigated for both the occupationally exposed and control groups before and after exposure to 2 Gy γ-rays as a challenge dose.
The results showed that an elevated frequency of CA, MN and nucleoplasmic bridge (NPB) was recorded in radiation workers (exposed group) compared to control group. However, after 2Gy
in vitro irradiation of lymphocytes of exposed and control groups, the exposed group was found to be lower than that of control group.
On the other hand, IL-1β and NO concentrations in plasma were elevated in exposed group more than in control group. While, after 2Gy irradiation for both groups, there are higher increment in the concentrations of IL-1β and NO in exposed group than the increment difference observed for control group after
in vitro irradiation as compared to the same group before irradiation.
The present results suggested the existence of an
in vivo cytogenetic adaptive response in individuals occupationally exposed to low dose of X-ray. In addition, the results showed that NO radicals and IL-1β have a role in the induction of radio-resistance due to in vivo exposure that may intermediate this radiation.

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