Procoagulant FVIII and Anticoagulant Protein C in Renal Failure Patients on Hemodialysis

Nosseir, Neveen M.; Tawfik, Mohamed S.; Bakheet, Ossama H.; El-Maghraby, Dina F.

doi:10.21608/ejrsa.2022.126870.1132

Procoagulant FVIII and Anticoagulant Protein C in Renal Failure Patients on Hemodialysis

Document Type : Original Article

Authors

¹ Health Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt

² Military Medical Academy, Cairo, Egypt

³ . Health Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt

10.21608/ejrsa.2022.126870.1132

Abstract

THE PREVALENCE of kidney diseases is increasing. Several population-based studies have shown that chronic kidney disease (CKD) increases the risk of venous thrombosis. Unfortunately, studies that describe this association are limited in providing explanatory information. The aim of the present study is to estimate the procoagulant Factor 8 (FVIII) and anticoagulant Protein C (PC) in patients on hemodialysis. Thirty patients (21 males, 9 females) diagnosed with end stage renal disease (ESRD) from those attending the hemodialysis unit of Aswan Armed Forces Hospital and 30 healthy controls were included in the current study. Assessment of glomerular filtration rate (GFR) was performed using 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT). Prothrombin time (PT) and partial thromboplastin time (PTT) were measured using a coagulation analysis apparatus. Plasma activities of PC and FVIII were measured automatically on IL coagulation system kit instrumentation. A significantly increased plasma level of FVIII and a significantly decreased plasma level of PC was found in patients with CKD on hemodialysis when compared to the control group (P= 0.0226 & 0.000103 respectively). Levels of FVIII were inversely associated with kidney function while there was a significant positive correlation between renal function and plasma PC levels in the group of patients. (r = - 0.27 & 0.53 respectively). It could be concluded that Patients with ESRD on hemodialysis were shown to have an increased coagulation tendency, especially with high FVIII and decreased protein C activities. The abnormal hemostatic profiles may contribute to the elevated risk of thrombotic events.

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