Evaluation of Antioxidant and Antitumor Activities of Moringa Extract in Mice

Document Type : Original Article

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Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt

Abstract

Cancer is a severe metabolic syndrome and is one of mortality leading causes worldwide. Radiation has important therapeutic benefits as a radiotherapy in malignant tumor, however it is also associated with serious adverse effects and thus reflecting the need to create or aid safer treatment. Moringa Oleifera (MO) is a promising plant that has a wide range of medicinal applications. Therefore, the present study was conducted to evaluate the effect of Moringa extract on implanted Ehrlich,s solid tumor in mice either alone or in association with radiotherapy.
Fifty male Swiss albino mice were implanted intramuscularly with Ehrlich ascites carcinoma (EAC) and were divided into five groups; group 1 (control) orally administred1 ml saline (3 days/week for 4 weeks) ,group 2 Ehrlich ascites carcinoma bearings mice (EAC), group3 EAC-bearing mice exposed to radio therapeutic dose two times/week for 4 weeks with dose (2GY), group 4: mice bearing EAC were orally administrated Moringa extract (500 mg/Kg b.w 3 days/week for 4 weeks) after one week of tumor implantation, group5 mice bearing EAC exposed to radio therapeutic dose and orally administered Moringa Oleifera extract after one week of tumor transplantation Radiotherapy of EAC-mice with Moringa Extract exhibited inhibition of tumor markers Her-2 and increased P53 also, improved blood parameters, lipid profile, oxidants and antioxidants levels, liver and kidney functions in EAC bearing mice. It could be concluded that Moringa Oleifera extract are potentially capable of exerting antitumor effect .

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