Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays

El Khalafawy, Gh. K.; Elkady, A. A.; El Bedewi, A. F.; Salah, M.

doi:10.21608/ejrsa.2023.212588.1154

Polyvinyl Alcohol/ gelatin/ silver Nanocomposites Treatment for Rats Skin Wound Irradiated by γ-rays

Document Type : Original Article

Authors

¹ Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt

² Radiation Research of Polymer Chemistry Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority(EAEA), Cairo, Egypt.

10.21608/ejrsa.2023.212588.1154

Abstract

Cutaneous wound healing is a complex process for the repair of damaged/ injured tissues; it is vital to find an effective method to boost skin healing. The aim of this work was to investigate the role of polyvinyl alcohol (PVA)/ gelatin/ silver nanocomposites, on wound healing. Thirty rats were equally divided into 5 groups as follow: 1) Normal intact skin (NS), 2) Topical garamycin (G), 3) γ-irradiated (8Gy), 4) Poly Vinyl Alcohol (PVA), 5) Poly Vinyl Alcohol+ γ-rays (PVA + γ-rays); rats in groups 2,3,4,5 were subjected to a surgical wound. Rats from each group were sacrificed on the 5^th and 21^st day from the surgical procedure. Histopathological and biochemical investigations (tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-8 (IL-8)) were evaluated in the wound region of the skin. Our results revealed that γ-irradiation delayed the healing process of rat’s skin wound with less reepitheliazation, prominent fatty tissues and higher levels of inflammatory markers PVA gelatin/ silver nanocomposites treatment enhanced healing process, as presented by both pathological and biochemical results. In Conclusion: PVA/ gelatin/ silver nanocomposites treatment may enhance skin healing.

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